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While there's no official upper limit, doses up to 2,000 mcg can be safely used to treat B12 deficiency under medical supervision

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[16] [17] adenosylcobalamin cyanocobalamin, the adenosyl ligand in vitamin B 12 is replaced by cyanide

In a study in South Africa, women said they felt there was a stigma to the pill -- a sexual partner might assume they're taking it because they already have HIV or because they have other partners