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NSCLC tumor samples have higher GSH levels and GSH uptake capacity compared to normal lung tissue, and higher plasma GSH levels have been found in patients with NSCLC who have undergone standard chemotherapy.31 In this context, high NRF2 levels in KEAP1-mutant NSCLC increase cell dependence on GSH and also lead to greater radiotherapy resistance through the influence of GSH.32 Overexpression of drug transport proteins is known to promote multidrug resistance in cancers

coli gene ynfA , which has also been found in Gram-positive and GNB species

This can lead to fatigue, immune weakness, brain fog, and slower recovery from illness or exertion

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doi: 10.1124/jpet.108.149807, 104

Once released, ellagic acid undergoes cleavage of a carbonoxygen bond, resulting in lactone ring opening, followed by a decarboxylation reaction that yields the first urolithin intermediate