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In summary, GPX7 is an essential sensor for oxidative stress and endoplasmic reticulum stress (Chen et al., 2016)

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GSSG is then reduced to GSH by glutathione reductase (GR) using reducing equivalent provided by NADPH

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Curcumin Attenuates Oxidative Stress in RAW264.7 Cells by Increasing the Activity of Antioxidant Enzymes and Activating the Nrf2-Keap1 Pathway

Overall, current evidence suggests that oxidative stress functions primarily as a context-dependent amplifier of necroptotic signaling rather than as a universal execution mechanism