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PRP remains the standard treatment for PDR, but it may lead to permanent peripheral visual field loss, reduced night vision, or worsen existing DME, increasing its occurrence [37]

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Neutrophils infiltrate diabetic kidneys via ICAM-1/MCP-1-mediated chemotaxis, releasing neutrophil extracellular traps (NETs) enriched in histones and proteases that induce podocyte detachment and tubular injury (83, 84)

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