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Immunocytochemistry For immunocytochemistry, cultured cortical neurons were fixed between DIV21 and DIV25 in 4% paraformaldehyde (PFA)/2% sucrose supplemented with 0.0025% glutaraldehyde (cat#: 16000, Electron Microscopy Sciences, Hatfield, PA) in PBS for 8 min at room temperature

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Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is the most common off-target adverse effects caused by various chemotherapeutic agents, such as cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib

While MRgFUS has its advantages, its important to note that its role is often considered investigational by insurance companies and other medical entities

Identifying subjects earlier in the disease course might provide the opportunity for testing the efficacy of an earlier UA intervention when the majority of dopaminergic neurons remain intact