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Activation of the glyoxylate shunt in response to low glucose is controlled by the transcriptional regulator RamB (Rv0465c) (Micklinghoff et al., 2009), while expression of genes involved in the methylcitrate cycle is regulated by PrpR (Rv1129c) (Masiewicz et al., 2012)

Conventional therapies, such as massage and electrical stimulation, failed to alleviate his symptoms

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