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For this variant, absorption changes associated with flavin reoxidation are exceptionally slow

101 This allelic variant has been suggested to potentially influence the stability of the GSTP1-1/JNK complex and, subsequently, JNK activity, contingent upon the redox status of the cell

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10.1016/j.jhep.2018.01.038 98 YuJ.-S.ChenW.-C.TsengC.-K.LinC.-K.HsuY.-C.ChenY.-H.et al (2016)

Taken together, the alteration to astrocytic glucose metabolism due to A accumulation and its effects on neighboring neurons points to metabolic alterations as being a key culprit in the development of AD

Like other GTPases, these Rac proteins exist in two conformations and the conversion between their inactive and active states is tightly regulated by several protein families, including GEFs, GAPs, and a guanine nucleotide dissociation inhibitor (Rho-GDI) (Hodge and Ridley, 2016)