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Theoretically, in response to various stimuli, TAM could be differentiated into distinct functional subsets, extremely into M1 phenotype macrophages by Th1 (IFN-, TNF, and LPS et al.), and into M2 by Th2 (IL-4, IL-10, TGF1, and PGE2 et al.) cytokines and immunocomplexes [17] (Fig