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The neuronal protective effects induced by KD also involved multiple pathways, such as modulation of ATP-sensitive potassium (K-ATP) channels, enhanced purinergic and GABAergic neurotransmission, increased expression of brain-derived neurotrophic factor (BDNF), attenuation of neuroinflammation, expansion of bioenergetic reserves, and stabilization of the neuronal membrane potential through improved mitochondrial function ( 3.3 The potential of a ketogenic diet to improve motor neuron function In the peripheral nervous system, mice fed a KD diet show increased epidermal axon density and neurite outgrowth in sensory neurons ( G93A ), the administration of KD was able to promote ATP synthesis by bypassing the inhibited complex I in the mitochondrial respiratory chain, increasing mitochondrial energy production and membrane stabilization, leading to increased motor neuron survival and improved motor function compared to normally fed mice

OC, optic chiasm

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