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Moreover, low levels of melatonin in AD patients correlate with the severity of cognitive symptoms and behavioral disorders [105]

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GLS, a pivotal enzyme in the catabolic pathway of glutamine, has emerged as a critical regulatory protein in the mechanism of cuproptosis (137)

E., Georgiu C., et al

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Irisin also significantly alleviates tubular epithelial cell injury and fibrosis by inhibiting Smad3 phosphorylation and suppressing the expression of Nox4 (a downstream regulator of ferroptosis) in the UUO mouse model, thus blocking Smad3-mediated ferroptosis (202)