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This mechanism is considered a physiological basis of the behavioral sickness response that humans and animals display during infections (Poon et al., 2015)

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These findings may explain the beneficial effects of selenium supplementation in autoimmune thyroid diseases (181, 194), such as reduced levels of anti-thyroid antibodies, improved thyroid structure and metabolism, and ameliorated clinical symptoms (181, 195)

Statistical analysis The data analyses were conducted using GraphPad Prism, version 8, developed by GraphPad Software in San Diego, CA, USA