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They are also observed in patients with sporadic PD, typically manifesting as late-onset PD closely resembling idiopathic PD in terms of clinical features and response to levodopa (Tolosa et al

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Activation of the IIS pathway inhibits several transcription factors, including DAF-16/Forkhead box O (FOXO), heat shock factor-1, and SKN-1/NRF2, thereby suppressing downstream target genes that promote longevity (Lee and Lee, 2022)

Agency for Toxic Substances and Disease Registry (ATSDR) (2012)

Overall, the findings of this systematic analysis show that the intake and status of Se are inadequate in Middle Eastern countries with much less consistency as per current measures of sustainability