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In conclusion, the typical clinical presentation of MTHFR deficiency includes neurological deterioration and vascular disorders

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These studies were deemed insufficient to warrant changes because they: (1) relied on mothers self-reported APAP usage, (2) lacked precise quantification of APAP dosage, and (3) frequently utilized questionnaire-based methodologies

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Legacy Category D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans

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