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[Google Scholar] 110.Bengtsson BA, Eden S, Ernest I, Oden A, Sjogren B

Tumour-induced immune modulation of sentinel lymph nodes

Upon T cell exhaustion during chronic infection or tumorigenesis, glycolysis and OXPHOS were suppressed by the PD-1-PD-L1 pathway, which reduced glucose uptake and repressed expression of PGC-1- [59, 60], and this metabolic dysregulation led to lost proliferative capacity, referred to as the terminally exhausted phenotype [59, 76, 77]
When patients begin the use of dextroamphetamine and Adderall, doctors will often prescribe these medications at low doses and gradually increase the dose as patients begin to adjust to the medication and start to feel differences in their symptoms

doi: 10.1126/scitranslmed.aag2942 108 KlionskyDJAbdel-AzizAKAbdelfatahSAbdellatifMAbdoliAAbelSet al

Taguchi K, Motohashi H, Yamamoto M (2011) Molecular mechanisms of the Keap1Nrf2 pathway in stress response and cancer evolution
