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Despite having a low immune risk of matching, including being a white individual with a living donor renal receptor, brief cold ischemia duration, and absence anti-HLA antibodies (DSAs or other), the patient developed intense acute T cell-mediated rejection occurred within a 48-hour timeframe after the surgery

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Furthermore, intracellular inclusions containing ubiquitin and ubiquitin ligases were detected in familial ALS mutant mice, suggesting that mutant SOD1 is resistant to the UPS

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Overall, RLT holds great promise as a targeted therapeutic strategy, offering precision targeting of cancer cells and efficacy in the treatment of cancer while minimizing adverse effects on healthy tissues
