intracellular glutathione pools are heterogeneously concentrated Nanomedical approaches to deplete in oncology Redox State of Glutathione and

Na 2 S 2 O 3 , a clinically approved H 2 S donor with little side effects, used for the treatment of cyanide poisoning, 481,482 calcific uremic arteriolopathy, and chemotherapy-induced nephrotoxicity (Table 4)

279 , H2649H2657 (2000)

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In addition, the expressions of Bax (Figure 4B), Bcl-2 (Figure 4C), and Casp3 (Figure 4D) genes, which are involved in the cell death signaling pathway (apoptosis), were measured, and the results indicated overexpressions of Bax and Casp3 genes and a downregulation of Bcl-2 in the 6-OHDA-exposed cells

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