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Supplementation with -alanine, a precursor of muscle carnosine, has also been proposed

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These coordinated damages across multiple brain regions collectively disrupt the neural circuits governing emotion regulation, cognitive execution, and motivational reward, ultimately resulting in the core clinical symptoms of persistent low mood, anhedonia, executive dysfunction, and cognitive impairment in patients (Troubat et al., 2021

This process allows concentration from the micromolar plasma concentrations to intracellular concentrations in the millimolar range [8], [121]

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