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Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1

In most healthy cells, this ratio is maintained in a highly reduced state between 30:1 and 100:1

The Treated group received a 5-day oral treatment course of 100 mg/kg phenformin (once daily for 5 days, D-2 to D2), whereas the Vehicle group received sterile water