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showed dietary curcumin prevents LPS-induced neuroinflammation and cognitive impairment in rats by modulating JNK/NF-B/Akt signaling (Khan et al., 2019)

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The TSS pathway is active in the liver and brain

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[DOI] [PubMed] [Google Scholar] 28.Davis S.R., Stacpoole P.W., Williamson J., Kick L.S., Quinlivan E.P., Coats B.S., Shane B., Bailey L.B., Gregory J.F., 3rd Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

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May 2006

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While the mechanism(s) is likely to be complex, use of a mutant SPT construct caused an accumulation of deoxysphingolipids that compromised endocytosis, a mechanism by which cells import nutrients necessary for proliferation and expansion (16)

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Greater detail regarding statistical significance is presented in the results of the main text and the online supplement (S1 Appendix)

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