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It can participate in one-carbon metabolism through serine hydroxymethyltransferase (SHMT) to support nucleotide synthesis, and can also serve as a component of glutathione (GSH) in maintaining cellular redox homeostasis ( Threonine (Thr) can likewise enter the one-carbon metabolic network and can be converted by threonine dehydrogenase (TDH) into intermediates such as acetyl-CoA, thereby providing a link between energy metabolism and epigenetic regulation ( Overall, the effects of Ser/Gly/Thr metabolism on macrophage polarization are mainly mediated by changes in one-carbon metabolic flux, methyl donor availability, and redox homeostasis, and the resulting outcome is often manifested as threshold regulation of inflammatory transcriptional programs and alterations in phenotypic stability

In silico analysis also demonstrates potential inhibition of the coronavirus main proteinase (Mpro) which would be an additional mechanism of inhibiting viral replication 7

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Glutathione also plays a major part in redox signaling, xenobiotic detoxification, the regulation of cell proliferation, apoptosis, immune function, and fibrogenesis

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