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doi:10.1016/s2468-1253(21)00024-8 114Live attenuated vaccines: avoid use in those who are clinically immunosuppressed

Exposure to hyperandrogen drives ovarian dysfunction and fibrosis by activating the NLRP3 inflammasome in mice

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Allen M, Huang B, Notaras M, Lodhi A, Barrio-Alonso E, Lituma PJ, Wolujewicz P, Witztum J, Longo F, Chen M, Greening DW, Klann E, Ross ME, Liston C, Colak D (2022) Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling

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Neuroimaging biomarkers also offer substantial predictive value, for example, reduced DAT uptake on PET scans can detect dopaminergic deficits 510 years before clinical symptom onset and help predict conversion to manifest PD [248, 249]
