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The impairment in fear extinction is the most commonly observed phenotype in the GAD67 knockout/knockdown model animals (Table 1)

In all these cases, the goal is to correct deficiency and prevent complications

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doi: 10.1056/NEJMoa020057 39 RiedlerJBraun-FahrlnderCEderWSchreuerMWaserMMaischSet al

Functional tests in yeast indicated that such modifications may alter the metal chelation of the plant MT proteins