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To further characterize the feature of new OL genesis during whole course of this model, we further took the advantage of our recently identified OL lineage cell stage-specific marker, ENPP6, a choline-specific ecto-nucleotide pyrophosphatase /phosphodiesterase (ENPP), which is highly expressed in newly-forming/formed OLs and at a much lower levels in these more mature/old (earlier-formed) myelinating OLs (to the extent that the ISH signal would easily disappear if the development time were shortened), but not at all in OPCs, neurons, astrocytes or vascular endothelial cells (Xiao et al., 2016

Int J Cancer 56(1):4651 Turrini E, Ferruzzi L, Fimognari C (2014) Natural compounds to overcome cancer chemoresistance: toxicological and clinical issues

Antiadrenergic autoimmunity in postural tachycardia syndrome

Bcl-2 overexpression protects hair cells from aminoglycoside exposure both in vitro and in vivo (Cunningham et al., 2009

One of the well-known senolytic drugs, Navitoclax, also holds the potential for use in One-Two Punch therapy [138]

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