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(2012), 9cRA was repeatedly administered through the intra-nasal route as intracerebral delivery is not feasible for repeated drug administration and may require chronic cannulation, whereas small molecules bypass the bloodbrain barrier and reach brain parenchyma non-invasively if delivered via the intranasal route

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[DOI] [PubMed] [Google Scholar] 823.Asmar A.E., Bendavides M., Moreau M., Hendlisz A., Deleporte A., Khalife M., Donckier V., Liberale G

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The sprays contain substances such as melanotan 2 a synthetic hormone not approved for use in the UK which can cause nausea, vomiting, high blood pressure, kidney problems, and an increased risk of melanoma skin cancer