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Not all drugs need to reach the systemic circulation to exert their effects, for example, oral vancomycin used to treat pseudomembranous colitis
Emory UniversityAnne M
Gabapentin is an epilepsy drug, which means it treats seizures
Sporadic dosing, skipping doses frequently, or constantly changing protocols prevents achieving steady-state effects
doi:10.1186/s40168-016-0171-4
Archiv Psychiatr Nervenkrankheit 1944;117:76-136
