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Methionine, in the form of S-adenosylmethionine (SAM), is required for many methylation reactions, including DNA methylation

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These include oxidative damage, epigenetic remodeling, endocrine disruption, chronic inflammation, changes in the tumor microenvironment, and the emergence of distinct mutational patterns [12]

The retraction is permanent and the paper should no longer be cited as evidence for the HGF/c-Met mechanism, although the underlying mechanism has been corroborated in subsequent independent work (e.g., Sun et al

Most patients tolerate these injections well, though mild soreness or bruising at the injection site may occur and typically resolve within 48 hours