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Exposure to ATZ reduces the mRNA expression of steroidogenic genes ( StAR , CYP17A1 , and 17-HSD ) which is directly linked to decreased androgenesis, thus, impairs the steroidogenesis of Leydig cells 108

The cycle is completed when the keto intermediate is cleaved between C2 and C3 by thiolysis by a 3-ketoacyl-CoA thiolase with acetyl-CoA and the CoA ester of a fatty acid two carbons shorter than the original as the products

doi: 10.1172/JCI200318921

Adverse reactions were usually transient, mild or moderate in severity and dose-dependent

[DOI] [PubMed] [Google Scholar] 59.Yago K, Tanaka Y, Asanami S

It is not approved and online products are unregulated, so safety is not assured