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The nuclear translocation of Nrf2 was determined through immunofluorescence (IF) analysis

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Glutathione is a vital antioxidant found in nearly all human cells, essential for reducing oxidative stress and supporting immune function, liver detoxification, and inflammation control.

Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO), prior to ASA treatment, cytotoxicity of the drug is augmented

Based on our RNA sequencing data, inhibition of SLC25A11 reduces NRF2 expression and translocation, resulting in loss of interaction affinity with the ferroptosis suppressor FSP1 and subsequent reactivation of the ferroptosis machinery

Organic Lions Mane (Hericium erinaceus)