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Keywords: Metformin, Vitamin B12 deficiency, Metformin-induced cobalamin deficiency, Diabetes, Type 2 diabetes, Prediabetes, Screening criteria, Neuropathy, Anemia Core Tip: Over the last decades, vitamin B12 deficiency has been increasingly recognized as a possible consequence of long-term metformin therapy, potentially resulting in clinical manifestations such as hematologic abnormalities and peripheral neuropathy

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Semaglutide (Wegovy) is FDA-approved for chronic weight management (with criteria) and has strong clinical trial evidence for meaningful average weight loss when paired with lifestyle support

Patients should verify that clinics are registered with appropriate regulatory bodies (CQC in England, HIS in Scotland, HIW in Wales, or RQIA in Northern Ireland) and that practitioners hold appropriate professional registration (GMC, NMC, HCPC or GPhC)

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