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7 Although the mechanism of NNMT in tumorigenesis remains to be delineated, upregulation of NNMT enzymatic activity has been suggested to lower the SAM/SAH ratio and alter the epigenetic landscape in cancer cells, as its expression level is inversely proportional to the SAM/SAH ratio

doi: 10.1186/s13018-021-02771-1

387 The efficacy of LDHA inhibitors is limited due to LDH between different tumors and metabolic reprogramming-mediated LDH isoform transformation

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation (in Eng)