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In silico analysis by enrichment revealed common pathways across NMS, including oxidative stress response, mitochondrial dysfunction, and protein aggregation

doi: 10.1016/j.cmet.2008.12.012

There is a preferential transport of GSSG from the cytosol to the endoplasmic reticulum to maintain an adequate environment for protein disulfide bond formation and protein folding ( Glutathione and the -glutamyl cycle The synthesis, transport and catabolism of GSH occur in a series of enzymatic steps and transports of membrane that are collectively called -glutamyl cycle (Figure 5) ( - glutamyl cycle was postulated by Meister (Figure 5)

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CoQ10 levels decrease with aging

The wide application of dihydromyricetin (DHM) is attributed to its exceptional pharmacological effects