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The reductive shift in the cytoplasmic [NADPH]/[NADP + ] in several brain regions with fasting is consistent with the reductive shift in the cytoplasmic [NAD + ]/[NADH] in some brain regions with fasting mentioned above and the inverse link between the pyruvate/lactate and the malate/pyruvate

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The role of the RB protein in promoting ferroptosis has also been observed in HCC, indicating the broader applicability of this strategy