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doi: 10.1038/s41422-020-0379-5 258 SiesH

Niflumic acid is also a TRPV1 channel antagonist and it was reported that peripheral neuropathy by suppressing excessive ROS, RNS, inflammatory cytokine production and TRPV1 activation in neuropathic pain-induced rats were recovered by the niflumic acid treatment (Marwaha et al., 2016)

Iron is required for Fenton Chemistry, but LOXs are non-heme iron-containing proteins whose function could be regulated by iron levels.35 Further studies are necessary to determine the relative contribution of iron to both pathways

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