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Glutathione transferase P1: potential therapeutic target in ovarian cancer

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& Dissanayake, V

Findings of Zechmann and co-workers (2010) that GSH concentrations are the highest in mitochondria, and that even in situations of permanent GSH deficiency, these levels are maintained at the expense of other subcellular GSH pools is interesting for future research

Under physiological conditions the potential for free radical-mediated damage is kept in check by the antioxidant defense system (AODS), comprising a series of enzymatic and non-enzymatic components

79,80,81 PiRNAs can also act as promoters or suppressors of tumor development by regulating DNMT expression and DNA methylation