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We then used Fishers r -to- z transformation to test the significance of difference between the correlations, and found that the correlation between glutamate and GSH was significantly weaker in patients compared to the healthy control subjects ( Z = 2.26, p = 0.023) (see Fig

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POAG has a clear genetic foundation, with heritability amongst twins ~0.95, and siblings of affected individuals having nearly an eight-fold increase risk of developing the disease