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In addition to risk of vitamin B12, calcium, iron and magnesium malabsorption, there is evidence that acid suppression by PPIs increases risk of malabsorption of other important vitamins and minerals as well, including vitamin C, zinc and folic acid.[231- 235] Proton pump inhibitor therapy lowers the concentration of vitamin C in gastric juice and the proportion of the vitamin in its active antioxidant form i.e., ascorbic acid

Due to the increased rise in cardiovascular mortality, those with chronic kidney disease (CKD) or end-stage renal disease (ESRD) have a significantly shorter life expectancy than people with adequate renal function [7]

56 , 57 Another study in patients with DTC found that vitamin C (especially in combination with amifostine) can reduce the side effects of radioiodine therapy