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Recently, the same group went on to identify an important A disintegrin and metalloprotease 17 (ADAM17)-regulated 1 -AR cleavage site at Arg31-Leu32 in the N-terminus, shown to be a key contributor to H 2 O 2 -dependent 1 -AR downregulation and decreased catecholamine responsiveness in cardiomyocytes (Zhu and Steinberg, 2021)

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Extensive research has established glutathione peroxidase 4 (GPX4) as a critical regulator in the pathogenesis of multiple pathological conditions, including osteoarthritis 35 ,cancers 47 , and liver disease 48

Accordingly, basic FGF (bFGF) (EssexBio, Zhuhai, Peoples Republic of China) dissolved in saline was used

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