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As copper is a cofactor in tumor angiogenesis, and its high levels influence tumor growth [110], Cu agents potentially can be used for BRAFV600E mutation-positive malignancies treatment and tumors resistant to BRAFV600E and MEK1/2 inhibitors [111]

the patients in this study all had systemic allergies and may represent a patient subset that is more likely to respond to hydroxyzine

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High-quality randomized trials focused specifically on weight outcomes in non-deficient populations would clarify these uncertainties
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