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In the foundational mouse study, MOTS-c prevented diet-induced obesity and reversed insulin resistance without changes in food intake or exercise (Lee et al

Until we know how to separate those effects, using BPC-157 in humans is a gamble with uncertain odds

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To make sure this medicine is safe for you, tell your doctor if you have: eye problems or Leber's disease (in you or a family member)

The closest comparators are tesamorelin (a GHRH analog with FDA approval for HIV-related fat) and SS-31 (a separate mitochondrial peptide that targets cardiolipin rather than AMPK)