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A distinctive sign of the disease is dermatitis, which presents as well-defined erythematous and eczematous plaques, erosions, scabs, and even blisters (254, 255)

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The differences in injecting participants mean percentage of abstinence between the 2 maintenance dose groups (Table 2) mainly reflect the difference in the proportion of participants with opioid abstinence between the maintenance dose groups, among those injecting participants who remained on the maintenance dose (Fig

A five-month study in mice administering 20% D-mannose via drinking water reported no adverse effects on body weight, organ function, metabolism, or reproductive parameters, suggesting good tolerance even at high doses 26