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doi: 10.1016/j.ejogrb.2007.02.014

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Subsequently, Chalcone synthase then catalyzes the condensation of 4-coumaroyl-CoA with malonyl-CoA to produce a chalcone, which is rapidly isomerized into a flavanone by chalcone isomerase (CHI) (Winkel-Shirley, 2001)

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They were advised to avoid sun exposure and refrain from applying any other whiteners, moisturizers, make-up, or skin care products on the test sites or from taking oral supplements such as Vitamins C, E, and A, which could improve the condition of their skin

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