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Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a heptapeptide ACTH(4-7)PGP analogue, exerts direct CNS effects through melanocortin 4 receptor (MC4R) activation, BDNF-TrkB neurotrophin upregulation, glucocorticoid receptor (GR) modulation, and dopaminergic/serotonergic circuit normalisation

Each element amplifies the others

Standard stacking protocols run both peptides simultaneously at their typical individual dosages

While HCG works through one mechanism, tirzepatide engages multiple appetite-control pathways simultaneously, potentially creating a synergistic effect when combined strategically

The compounding pathway sits separately from prescriber obligations on informed consent, pharmacy verification, documentation, and malpractice exposure

Should Athletes Assume Peptides Are Undetectable