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The logic is to front-load exposure while the tissue is remodeling, then taper to a maintenance rhythm that sustains the effect at a fraction of the vial cost
doi: 10.1530/EJE-13-0503 50 ColaoASarnoADCappabiancaPBrigantiFPivonelloRSommaCDet al
It should be noted that, however, the Epiderm we adopted for the present study is a commercially available human epidermal equivalent, which effectively provides a non-animal means to assess dermal toxicology and skin research issues 48
