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The developed FA-SNCD@SBA-15/ENZ multifunctional nanocarrier showed higher cytotoxicity compared with the untreated drug and nanoparticles in the PC3 human prostate cancer cell line.

Despite decreases in most splenic leukocyte subsets, there were increases in reactive oxygen species (ROS)-related activity

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Specifically, the synergistic action of metformin and simvastatin reshaped glioma metabolism, curbed malignant proliferation, promoted apoptosis, and demonstrated superior anti-tumor effects both in vitro and in vivo compared to individual administration of metformin or simvastatin

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