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The brain is the second most lipid-rich organ in the body 9

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10,11,17 The combinations of amantadine with interferon-alpha or IL-29 resulted in stronger inhibitory effects on HAV replication compared with amantadine alone

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Another mechanism may involve activation of sirtuins, especially sirtuin1 (SIRT1) and its transcriptional co-factor peroxisome proliferator-activated receptor- coactivator 1 alpha (PGC-1), although few data of human studies are available 26