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Tau-1 contains a nuclear receptor box, FQNLF (amino acids 2327), and Tau-5 contains the WHTLF motif (amino acids 433437), both of which mediate direct ligand-dependent, interdomain interactions between the NTD and the LBD (termed an N/C interaction), which are important in regulating some, but not all, androgen-dependent genes 40,41,42

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-Lipoic acid enantiomers and its reduced form have antioxidant, cognitive, cardiovascular, detoxifying, anti-aging, dietary supplement, anti-cancer, neuroprotective, antimicrobial, and anti-inflammatory properties

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Conflict of Interest The authors declare that they have no competing interests

It doesnt replace those inputs