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A study by Pickart et al

DIO studies in female PAR2 mutant mice gave concordant results, and female PAR2-R38E mice showed only a tendency toward reduced weight gain (Figure 3B)

[37] Nguyen MQ, von Buchholtz LJ, Reker AN, Ryba NJP, Davidson S

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doi: 10.1186/s12889-023-16954-4 392

It is by these means that the interplay of these free radical sources is thought to cause ROS damage by OH to the surrounding tissues including the peritoneum, oviduct, ovary, and the follicle, oocyte, sperm and embryos (84, 85, 103113)