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This observed cytotoxicity may be attributed to the elevated uptake of GSH and/or -EC, potentially disturbing GSH homeostasis

Am J Gastroenterol 92:5S-11S Savilahti E, Orml T, Saukkonen T et al (1999) Jejuna of patients with insulin-dependent diabetes mellitus (IDDM) show signs of immune activation

Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis

Published data on lobe differences in endogenous and induced enzymes is scarce, although many researchers suspect there may be important lobe differences based on differential blood flow (Wilson and Hiley 1983) and the observation of lobe differences in toxic responses

One registered Phase 1 trial in healthy volunteers exists for an oral formulation (NCT02637284)

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