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Purity grade matters significantly for GI and neural research designs because copper-contaminated or low-purity batches introduce confounding variables that make mechanistic interpretation unreliable

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References 1 AlbanisE.FriedmanS

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Clinical studies showed that post-colonoscopy CB supplementation can upregulate the expression of the buk gene (encoding butyrate kinase), enhance butyrate production, and accelerate homeostasis of the microbiota and colonic mucosal microenvironment (75)