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The normal vascular endothelium regulates vasodilation and vasocontraction, proliferation and antiproliferation of vascular smooth muscle cells, coagulation and anticoagulation, inflammation and anti-inflammation, and oxidation and antioxidant effects, which work in balance to regulate and maintain vascular tone and structure [53]

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's_Orthopaedic_Surgery_Chapter_273 Accessed June 26, 2019

Today, oxidative stress remains a central principle in aging theories, with mitochondria and NOX as key systems generating excessive oxidative stress (Fig